Scientists have detailed the benefits of a particular diet consisting of fruit, avocado, whole grains, and fish in lowering inflammation and oxidative stress in obese people in a research published in the journal Nutrients.
Being overweight and obese has elevated global public health concerns. Recent estimates indicate that about 1.9 billion people worldwide are overweight, including over 650 million who are obese. Obesity raises the risk of cancer, diabetes, and other metabolic and cardiovascular illnesses.
Obesity-related functional impairment of adipose tissue is linked to the development of a persistent low-grade inflammatory state, which in turn is the cause of the emergence of chronic illnesses.
The secret to controlling body weight is a strict commitment to a healthy lifestyle, which includes a nutritious diet and regular physical exercise. Examples of wholesome diets that are proven to lessen inflammation and oxidative stress brought on by obesity are the Mediterranean diet and the Nordic diet.
In the current study, researchers assessed the effects of a meal high in fruit, avocado, whole grains, and fish on the postprandial expression of genes linked to inflammation and oxidative stress in obese persons living in Colombia.
44 obese people with BMIs of more than 30 kg/m2 who had no known chronic conditions were included in the research. 25 of the individuals followed the experimental diet for eight weeks, whereas 19 followed the control diet.
The trial diet included fruits, avocados, whole grains, fish, and other staples of the Colombian coffee-growing region. The participants’ typical daily fare, including high-saturated-fat meals, processed carbs, and low-fiber foods, made up the control diet.
After the dietary intervention was complete, the postprandial expression of genes associated with inflammation and oxidative stress (NFKB1, RELA, IKKA, MMP9, TNF, IL1, IL6, and NFE2L2) was assessed 0–4 hours after meal consumption.
Following the experimental diet resulted in a significantly lower body weight and body mass index (BMI) when the clinical parameters of the subjects were assessed eight weeks after the start of the diet. Individuals following the control diet did not have this impact.
Gene expression linked to oxidative stress and inflammation
The expression of three inflammation-related genes, nuclear factor kappa B subunit 1 (NFKB1), interleukin 6 (IL6), and IL1, is dramatically reduced by the experimental diet, according to an analysis of postprandial gene expression based on real-time polymerase chain reaction (RT-PCR).
Nuclear factor erythroid-derived 2-like 2 (NFE2L2) expression was shown to be significantly lower in relation to oxidative stress-related genes following the 8-week experimental diet intervention. Following the control diet, no such impact was seen.
Analysis of comparison
The study compared numerous biochemical markers with the expression levels of the investigated genes.
Individuals on the experimental diet showed an NFKB1 expression and blood triglyceride level connection that was statistically significant and positive 4 hours post-meal. The expression of IL1 and blood insulin levels were shown to be significantly positively correlated 4 hours after meals among individuals in the control diet group.
The study emphasizes the significance of a balanced diet in lowering inflammation and oxidative stress linked to obesity through the control of gene expression. The dietary intervention investigated here is abundant in fish, whole grains, avocado, and traditional fruits from the Colombian coffee area.
According to the researchers, particular nutrients in the diet, such as the good fats found in avocado and trout, may have an immediate impact on the transcription factors that regulate the expression of genes linked to obesity.
Fruits are a significant source of vitamins and phenolic compounds in the diet being investigated. These nutrients’ antioxidant qualities may directly influence the expression of genes associated with oxidative stress for the better.
Overall, the research suggests that treating obesity-related issues may be facilitated by following an eight-week diet high in fruit, avocado, whole grains, and fish.